Sox18 induces development of the lymphatic vasculature in mice
Identifieur interne : 006F76 ( Main/Exploration ); précédent : 006F75; suivant : 006F77Sox18 induces development of the lymphatic vasculature in mice
Auteurs : Mathias Francois [Australie] ; Andrea Caprini [Italie] ; Brett Hosking [Australie] ; Fabrizio Orsenigo [Italie] ; Dagmar Wilhelm [Australie] ; Catherine Browne [Australie] ; Karri Paavonen [Australie] ; Tara Karnezis [Australie] ; Ramin Shayan [Australie] ; Meredith Downes [Australie] ; Tara Davidson [Australie] ; Desmond Tutt [Australie] ; Kathryn S. E. Cheah [Hong Kong] ; Steven A. Stacker [Australie] ; George E. O. Muscat [Australie] ; Marc G. Achen [Australie] ; Elisabetta Dejana [Italie] ; Peter Koopman [Australie]Source :
- Nature : (London) [ 0028-0836 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The lymphatic system plays a key role in tissue fluid regulation and tumour metastasis, and lymphatic defects underlie many pathological states including lymphoedema, lymphangiectasia, lymphangioma and lymphatic dysplasia1-3. However, the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear. Lymphatic vessels are thought to arise from endothelial precursor cells budding from the cardinal vein under the influence of the lymphatic hallmark gene Proxl (prospero homeobox 1; ref. 4). Defects in the transcription factor gene SOX18 (SRY (sex determining region Y) box 18) cause lymphatic dysfunction in the human syndrome hypotrichosis-lymphoedema-telangiectasia5, suggesting that Soxl8 may also play a role in lymphatic development or function. Here we use molecular, cellular and genetic assays in mice to show that Soxl8 acts as a molecular switch to induce differentiation of lymphatic endothelial cells. Soxl8 is expressed in a subset of cardinal vein cells that later co-express Proxl and migrate to form lymphatic vessels. Soxl8 directly activates Prox1 transcription by binding to its proximal promoter. Overexpression of Soxl8 in blood vascular endothelial cells induces them to express Proxl and other lymphatic endothelial markers, while Sox18-null embryos show a complete blockade of lymphatic endothelial cell differentiation from the cardinal vein. Our findings demonstrate a critical role for Soxl8 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies.
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E." last="Cheah">Kathryn S. E. Cheah</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Biochemistry and Centre for Reproduction, Development & Growth, University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Muscat, George E O" sort="Muscat, George E O" uniqKey="Muscat G" first="George E. O." last="Muscat">George E. O. 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Milan</s1><s2>20129 Milan</s2><s3>ITA</s3><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0035295</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 09-0035295 INIST</idno><idno 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4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Caprini, Andrea" sort="Caprini, Andrea" uniqKey="Caprini A" first="Andrea" last="Caprini">Andrea Caprini</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16</s1><s2>20139 Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Hosking, Brett" sort="Hosking, Brett" uniqKey="Hosking B" first="Brett" last="Hosking">Brett Hosking</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Orsenigo, Fabrizio" sort="Orsenigo, Fabrizio" uniqKey="Orsenigo F" first="Fabrizio" last="Orsenigo">Fabrizio Orsenigo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16</s1><s2>20139 Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Browne, Catherine" sort="Browne, Catherine" uniqKey="Browne C" first="Catherine" last="Browne">Catherine Browne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Paavonen, Karri" sort="Paavonen, Karri" uniqKey="Paavonen K" first="Karri" last="Paavonen">Karri Paavonen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Surgery, The University of Melbourne</s1><s2>Parkville, Victoria 3052</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Parkville, Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Downes, Meredith" sort="Downes, Meredith" uniqKey="Downes M" first="Meredith" last="Downes">Meredith Downes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Davidson, Tara" sort="Davidson, Tara" uniqKey="Davidson T" first="Tara" last="Davidson">Tara Davidson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Tutt, Desmond" sort="Tutt, Desmond" uniqKey="Tutt D" first="Desmond" last="Tutt">Desmond Tutt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Cheah, Kathryn S E" sort="Cheah, Kathryn S E" uniqKey="Cheah K" first="Kathryn S. E." last="Cheah">Kathryn S. E. Cheah</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Biochemistry and Centre for Reproduction, Development & Growth, University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>13 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Muscat, George E O" sort="Muscat, George E O" uniqKey="Muscat G" first="George E. O." last="Muscat">George E. O. Muscat</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital</s1><s2>Victoria 3050</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3050</wicri:noRegion></affiliation></author><author><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16</s1><s2>20139 Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Biomolecular Sciences and Biotechnologies, University of Milan</s1><s2>20129 Milan</s2><s3>ITA</s3><sZ>17 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Molecular Bioscience, The University of Queensland</s1><s2>Brisbane, Queensland 4072</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature : (London)</title><title level="j" type="abbreviated">Nature : (Lond.)</title><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animal model</term><term>Gene overexpression</term><term>Lymphangiectasis</term><term>Lymphangiogenesis</term><term>Lymphangioma</term><term>Lymphatic</term><term>Lymphatic system</term><term>Lymphedema</term><term>Mouse</term><term>Pathophysiology</term><term>Transcription factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Souris</term><term>Lymphatique</term><term>Système lymphatique</term><term>Facteur transcription</term><term>Lymphangiectasie</term><term>Animal</term><term>Physiopathologie</term><term>Modèle animal</term><term>Lymphangiome</term><term>Surexpression génique</term><term>Lymphoedème</term><term>Lymphangiogénèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system plays a key role in tissue fluid regulation and tumour metastasis, and lymphatic defects underlie many pathological states including lymphoedema, lymphangiectasia, lymphangioma and lymphatic dysplasia<sup>1-3</sup>. However, the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear. Lymphatic vessels are thought to arise from endothelial precursor cells budding from the cardinal vein under the influence of the lymphatic hallmark gene Proxl (prospero homeobox 1; ref. 4). Defects in the transcription factor gene SOX18 (SRY (sex determining region Y) box 18) cause lymphatic dysfunction in the human syndrome hypotrichosis-lymphoedema-telangiectasia5, suggesting that Soxl8 may also play a role in lymphatic development or function. Here we use molecular, cellular and genetic assays in mice to show that Soxl8 acts as a molecular switch to induce differentiation of lymphatic endothelial cells. Soxl8 is expressed in a subset of cardinal vein cells that later co-express Proxl and migrate to form lymphatic vessels. Soxl8 directly activates Prox1 transcription by binding to its proximal promoter. Overexpression of Soxl8 in blood vascular endothelial cells induces them to express Proxl and other lymphatic endothelial markers, while Sox18-null embryos show a complete blockade of lymphatic endothelial cell differentiation from the cardinal vein. Our findings demonstrate a critical role for Soxl8 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Hong Kong</li><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="Francois">Mathias Francois</name></noRegion><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><name sortKey="Browne, Catherine" sort="Browne, Catherine" uniqKey="Browne C" first="Catherine" last="Browne">Catherine Browne</name><name sortKey="Davidson, Tara" sort="Davidson, Tara" uniqKey="Davidson T" first="Tara" last="Davidson">Tara Davidson</name><name sortKey="Downes, Meredith" sort="Downes, Meredith" uniqKey="Downes M" first="Meredith" last="Downes">Meredith Downes</name><name sortKey="Hosking, Brett" sort="Hosking, Brett" uniqKey="Hosking B" first="Brett" last="Hosking">Brett Hosking</name><name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name><name sortKey="Muscat, George E O" sort="Muscat, George E O" uniqKey="Muscat G" first="George E. O." last="Muscat">George E. O. Muscat</name><name sortKey="Paavonen, Karri" sort="Paavonen, Karri" uniqKey="Paavonen K" first="Karri" last="Paavonen">Karri Paavonen</name><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name><name sortKey="Shayan, Ramin" sort="Shayan, Ramin" uniqKey="Shayan R" first="Ramin" last="Shayan">Ramin Shayan</name><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><name sortKey="Tutt, Desmond" sort="Tutt, Desmond" uniqKey="Tutt D" first="Desmond" last="Tutt">Desmond Tutt</name><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Caprini, Andrea" sort="Caprini, Andrea" uniqKey="Caprini A" first="Andrea" last="Caprini">Andrea Caprini</name></region><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><name sortKey="Orsenigo, Fabrizio" sort="Orsenigo, Fabrizio" uniqKey="Orsenigo F" first="Fabrizio" last="Orsenigo">Fabrizio Orsenigo</name></country><country name="Hong Kong"><noRegion><name sortKey="Cheah, Kathryn S E" sort="Cheah, Kathryn S E" uniqKey="Cheah K" first="Kathryn S. E." last="Cheah">Kathryn S. E. Cheah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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